Electrospray Ionization (ESI) Technique

Electrospray is a method by which ions present in a solution can be transferred to the gas phase. The process involves the application of an electric field across an interface which acts to form an electrochemical cell in the interface. This module discusses important parameters when carrying out electrospray ionization (ESI). Find out practical tips for overcoming ion suppression, optimizing sprayer position, and the role pH plays in signal intensity.

Topics include:

• Ion suppression principles
• Ion suppression in practice
• Mass dependence of the ion signal
• Optimizing the sprayer position
• Solute changes in evaporating droplets
• pH versus ion intensity